Dr. Manish Agarwal

Major Cancer Types Treated

• Bone Tumours
• Soft Tissue Tumours
• Paediatric Bone Cancers

Sub-specialties

• Orthopaedic Oncosurgery
• Musculoskeletal Oncology
• Limb Salvage Surgery
• Oncology Reconstructive Surgery
• Paediatric Orthopaedics (related to oncology)
• Bioengineering in Orthopaedics

Advanced Procedures Performed

• Surgical Resection of Bone & Soft Tissue Tumours
• Complex Limb Salvage Reconstructions
• Reconstructive Surgery for Cancer Defects
• Extracorporeal Irradiation and Reimplantation (ECRT)
• Development and Utilisation of International Quality Indian Implants
• Arthrodesis of the Wrist after Resection of Distal Radius and Ulna Translocation
• Management of Megaprosthetic Infections

Current & Past Hospital Affiliations

Current Affiliation:

• Nanavati Max Super Speciality Hospital, Mumbai (Principal Director & Head, Orthopaedic Oncosurgery)

Past Affiliations:

• Consultant Orthopaedic Oncosurgeon and Head, Section of Surgical Oncology at P.D. Hinduja National Hospital & MRC (February 2010 – September 2021)

Academic & Research Roles

• Associate Professor and Consultant Orthopaedic Oncologist, Tata Memorial Hospital, Mumbai (January 2000 – January 2010)
• Founder Member & Trustee, Indian Musculoskeletal Tumor Society (IMSOS)
• Member, Education Committee, International Society of Limb Salvage

Key Achievements & Contributions

• Instrumental in developing and advancing orthopaedic oncosurgery practices in India over two decades.
• Pioneered complex limb salvage techniques for patients with musculoskeletal tumours.
• Contributed significantly to the research and development of Indian implants for orthopaedic oncology.
• Mentored numerous budding orthopaedic oncologists and contributed to academic advancements in the field.

• Seth Jairamdas Berry Gold Medal for the highest marks in Pharmacology at Bombay University in 1986.
• Smt. Manorama Vijayraj Hazrat prize for highest aggregate marks at the 2nd MBBS examination of Bombay University in 1986.
• Gold Medal for Orthopaedic Surgery 2004 conferred by the Special Executive Magistrates Society, December 2004.
• A. A. Mehta Gold Medal for the best paper at the 49th National conference of the Indian Orthopaedic Association, December 2004.

Published Papers in Medical Journals

• Extended Curettage for Giant Cell Tumors of Bone, JBJS Essential Surgical Techniques, 2021.
• Laparoscopic excision of a schwannoma arising in the psoas muscle, Journal of Minimal Access Surgery, 2021.
• Does a Modified Technique to Achieve Arthrodesis of the Wrist After Resection of the Distal Radius and Translocating the Ipsilateral Ulna as a Vascularized Graft to Reconstruct the Defect Improve Grip Strength and Outcomes Scores?, Clinical Orthopaedics and Related Research®, 2020.
• Do irradiated osteo-articular recycled tumor autografts still hold promise for biological joint reconstruction? Our experience with acetabular and proximal ulna ECRT, Journal of Clinical Orthopaedics and Trauma, 2020.
• Chemokine SDF1 Mediated Bone Regeneration Using Biodegradable Poly (D, L-lactide-co-glycolide) 3D Scaffolds and Bone Marrow-Derived Mesenchymal Stem Cells: Implication for the Development of an “Off-the-Shelf” Pharmacologically Active Construct, Biomacromolecules, 2020.
• CORR Insights®: Ganglion Cysts of the Proximal Tibiofibular Joint: Low Risk of Recurrence After Total Cyst Excision, Clinical Orthopaedics and Related Research®, 2020.
• World-Class Tumor Knee Prosthesis: Made in India, Indian Journal of Orthopaedics, 2020.
• Tuberculosis (TB) masquerading as tumor. An 8-year study on 25 cases of long bone tuberculosis presenting as tumors, SICOT-J, 2020.
• Reconstructive Challenges of Proximal Ulnar Bone Tumors: Our Experience with Biological Osteoarticular Reconstruction Using Extracorporeal Irradiation and Reimplantation, Sarcoma, 2019.
• Extracorporeal radiation and reimplantation: a safe and viable option for reconstruction after sacral tumor resection?, Ann Transl Med, 2019.
• Bizarre Parosteal Osteochondromatous Proliferation–A Case Series of Typical and Atypical Presentations, Journal of Orthopaedic Case Reports, 2019.
• Modulatory effect of mast cells in the pathology of peri-prosthetic fibrosis around a retrieved knee implant, Clinical Cases in Mineral & Bone Metabolism, 2019.
• Radiation-Induced Wound Infections in Operated Soft Tissue Sarcomas: An Unbelievable Challenge in a Series of Five Cases, Journal of Orthopaedic Case Reports, 2019.
• Is Vitamin D deficiency behind the scenes for high incidence of Giant Cell Tumor amongst the Indian population? Unraveling the Vitamin D – RANKL association, Medical Hypotheses, 2018.
• Does Denosumab Change the Giant Cell Tumor Treatment Strategy? Lessons Learned From Early Experience, Clinical Orthopaedics and Related Research®, 2018.
• Safety and Pharmacokinetics of Withaferin-A in advanced stage high grade Osteosarcoma: A phase I trial, Journal of Ayurveda and Integrative Medicine, 2019.
• Growing Without Pain: The Noninvasive Expandable Prosthesis is Boon for Children with Bone Cancer, as well as Their Surgeons!, Indian Journal of Orthopaedics, 2019.
• Does Extracorporeal Irradiation and Reimplantation After Acetabular Resections Result in Adequate Hip Function? A Preliminary Report, Clinical Orthopaedics and Related Research®, 2018.
• CORR Insights®: Is Limb Salvage With Microwave-induced Hyperthermia Better Than Amputation for Osteosarcoma of the Distal Tibia?, Clinical Orthopaedics and Related Research®, 2017.
• Intralesional Curettage technique for Giant cell tumor of bone–current concepts and evidence, Journal of Bone and Soft Tissue Tumors, 2017.
• Indian data on bone and soft tissue sarcomas: A summary of published study results, South Asian J Cancer, 2016.
• Novel modification of second generation intramedullary PMMA cementing technique for narrow upper and lower extremity canals, J Clin Orthop Trauma, 2016.
• Giant Cell Tumor of Bone - An Overview, Arch Bone Jt Surg, 2016.
• Management of skeletal metastases: An orthopaedic surgeon's guide, Indian J Orthop, 2015.
• Role of Image Guided Interventions in Orthopaedic Oncology, Journal of Bone and Soft Tissue Tumors Volume, 2015.
• Pasteurization of bone for tumour eradication prior to reimplantation - An in vitro & pre-clinical efficacy study, Indian J Med Res, 2014.
• Adaptive probabilistic approach for selecting tumour knee prosthesis, Comput. Sci. Inf. Syst., 2013.
• Further opinion, J Bone Joint Surg [Br], 2012.
• Extramedullary versus intramedullary tibial cutting guides in megaprosthetic total knee replacement, J OrthopSurg Res, 2012.
• Osteosarcoma of the femur mimicking Ewing sarcoma/primitive neuroectodermaltumour on biopsy and metastatic carcinoma on resection, Skeletal Radiol, 2012.
• Alveolar soft part sarcoma 'revisited': clinicopathological review of 47 cases from a tertiary cancer referral centre, including immunohistochemical expression of TFE3 in 22 cases and 21 other tumours, Pathology, 2012.
• Phosphaturic mesenchymal tumor with chondromyxoid fibroma-like feature: an unusual morphological appearance, Skeletal Radiol, 2011.
• Joint-sparing or Physeal-sparing Diaphyseal Resections: The Challenge of Holding Small Fragments, ClinOrthopRelat Res, 2010.
• Revision of Broken Knee Megaprostheses: New Solution to Old Problems, ClinOrthopRelat Res, 2010.
• Interesting image. The search for primary tumor in a patient with oncogenic osteomalacia: F-18 FDG PET resolves the conundrum, ClinNucl Med, 2010.
• Extracorporeal irradiated tumor bone: A reconstruction option in diaphyseal Ewing's sarcomas, Indian J Orthop, 2010.
• Ulna translocation: an effective reconstruction modality after excision of Campanacci grade 3 giant cell tumours of distal radius, J Bone Joint Surg Br, 2010.

Patient Testimonials

“Dr. Manish Agarwal is an exceptional orthopaedic oncosurgeon. He saved my leg after a bone tumour diagnosis, which other doctors said would require amputation. His dedication and skill are truly remarkable.” - Anjali R.

“We are so grateful to Dr. Agarwal for treating our son’s bone cancer. He is not just a brilliant surgeon but also incredibly compassionate, making a difficult journey much easier for us.” - The Sharma Family

“My soft tissue sarcoma was expertly removed by Dr. Agarwal. He explained every step, ensuring I understood my treatment. I highly recommend him as a leading bone cancer specialist.” - Bharat S.

Patient-Centred Care: Dr. Manish Agarwal’s philosophy is deeply rooted in providing comprehensive, individualised care for patients with musculoskeletal tumours. He prioritises not only the eradication of cancer but also the preservation of limb function and the patient's quality of life through advanced limb salvage techniques and reconstructive surgery.

Technology & Innovation: Dr. Agarwal is at the forefront of orthopaedic oncology, embracing cutting-edge techniques such as extracorporeal irradiation and reimplantation and contributing to the development of specialised Indian implants. His research in bioengineering further highlights his commitment to innovative solutions for complex cases.

For appointment booking and to get a personalised cost estimate for treatments such as bone tumour surgery, limb salvage surgery, or soft tissue sarcoma resection, you can connect with the Cancer Rounds team.

Language Support: The Cancer Rounds team typically offers support for international patients, including language services, to ensure clear communication throughout the treatment journey with Dr. Manish Agarwal.

Visa & Travel Assistance: The Cancer Rounds team assists with visa processes, travel arrangements, airport transfers, and accommodation, providing comprehensive support for patients travelling to India for treatment.

Pre-treatment Virtual Consultations: Telemedicine capabilities are available for initial discussions, review of medical records, and second opinions with Dr. Manish Agarwal before international patients travel to India.