Prof. Dr. Andreas Mackensen

Hematologist

Prof. Dr. Andreas Mackensen

Head of Department

years of experience

Graduation
University Hospital Erlangen, Erlangen - Germany

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    Treatments & Conditions Prof. Dr. Andreas Mackensen Specializes In

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    Areas of Expertise

    Prof. Dr. Andreas Mackensen

    Major Conditions Treated

    • Acute Lymphoblastic Leukaemia (ALL) & Acute Myeloid Leukaemia (AML)
    • Chronic Lymphocytic Leukaemia (CLL) & Chronic Myeloid Leukaemia (CML)
    • Hodgkin and Non-Hodgkin Lymphomas (Including B-Cell NHL)
    • Multiple Myeloma
    • Myelodysplastic Syndromes (MDS)
    • Aplastic Anaemia & Bone-Marrow Failure Syndromes
    • Bleeding & Coagulation Disorders
    • Severe Autoimmune Diseases Eligible for CAR-T (Lupus, Systemic Sclerosis, Autoimmune Myositis)
    • Selected Solid Tumours (Coordinated through CCC Erlangen-EMN)
    • Patients Eligible for Autologous & Allogeneic Stem-Cell Transplantation

    Sub-specialties

    • CAR-T Cell Therapy & Cellular Immunotherapy: CD19-directed CAR-T, BCMA-directed CAR-T, IL-18-enforced CAR-T, double CAR-T strategies for hematological malignancies and severe autoimmune diseases — making him a leading Hematologist specialist Erlangen, Germany for CAR-T cell therapy.
    • Allogeneic Stem-Cell Transplantation & Leukaemia: Allogeneic and autologous SCT, GvHD/GvL management and clinical translation through DFG TRR221 — supporting demand for the best Hematologist doctor in Germany for stem-cell transplantation.
    • Lymphoma, Myeloma & Solid-Tumour Immunotherapy: B-cell lymphomas, multiple myeloma and CAR-T research for solid cancers (including GD2-positive solid tumours).

    Advanced Procedures & Treatments

    • CD19-Directed CAR-T Cell Therapy
    • BCMA-Directed CAR-T Cell Therapy
    • Cytokine-Engineered (IL-18-Armoured) CAR-T Cells
    • Double CAR-T Cell Therapy (Selected Cases)
    • Autologous Hematopoietic Stem-Cell Transplantation
    • Allogeneic Hematopoietic Stem-Cell Transplantation
    • Donor Lymphocyte Infusion (DLI)
    • Standard & Investigational Chemotherapy
    • Immunotherapy & Checkpoint Inhibitors
    • Targeted Therapy (BCR Inhibitors, BCL-2 Inhibitors, BiTE)
    • Multidisciplinary Tumour Board Coordination
    • Phase I / II / III Clinical Trials in Hematology & Cellular Therapy

    Qualifications & Credentials

    Medical Degrees

    • Studies in Human Medicine (Graduation) — Albert-Ludwigs-University of Freiburg, Germany, 1981–1988
    • Medical-Technical Laboratory Assistant Training — Germany, 1981 (prior to medical studies)
    • Doctorate (Dr. med.) — Germany
    • Habilitation (Venia Legendi) — Germany
    • Professor (Univ.-Prof.) of Internal Medicine — FAU Erlangen-Nürnberg

    Fellowships & Special Training

    • Specialist Certification (Facharzt) — Internal Medicine, Hematology & Medical Oncology
    • Sub-specialty training in Stem-Cell Transplantation, CAR-T Cell Therapy and Cellular Immunotherapy
    • Continuing professional development in immunotherapy, allogeneic SCT and clinical trial design

    Certifications & Accreditations

    • Bavarian State Medical Council — Registered Specialist in Internal Medicine, Hematology and Oncology
    • Active President — Bavarian Cancer Research Center (BZKF)
    • Speaker / Co-speaker of multiple DFG-funded research programmes (KFO146, TRR221)

    Professional Experience

    Current Affiliation

    • Director — Department of Medicine 5 (Hematology & Oncology), Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) (Present)
    • Director — Transplant Center, Universitätsklinikum Erlangen (Present)
    • Deputy Director — Comprehensive Cancer Center (CCC) Erlangen-EMN (Present)
    • Active President & Founding Director — Bavarian Cancer Research Center (BZKF) (Present)
    • Univ.-Prof. of Internal Medicine — FAU Erlangen-Nürnberg (Present)
    • Speaker for Erlangen — DFG Collaborative Research Center (CRC) Transregio TRR221 (Present)

    Past Affiliations

    • Albert-Ludwigs-University of Freiburg — Medical Studies, 1981–1988
    • Spokesman and Head — Clinical Research Group KFO146, DFG (Past)
    • Co-speaker — Transregio SFB TRR221, DFG (Continuing)
    • Member of Supervisory Board, Uniklinikum Erlangen (since 2012 – Present)

    Academic & Research Roles

    • Univ.-Prof. of Internal Medicine — FAU Erlangen-Nürnberg
    • Founding Director, Bavarian Cancer Research Center (BZKF), 2019
    • Spokesman and Head — Clinical Research Group KFO146 (DFG)
    • Co-speaker — DFG Transregio SFB TRR221
    • Erlangen is one of the few academic centres permitted to produce CAR-T cells in Europe (since 2019) — under his leadership
    • Author of high-impact publications in Nature Medicine, The New England Journal of Medicine, Lancet and Blood

    Key Achievements

    • Pioneer of CAR-T cell therapy for severe autoimmune diseases (with Prof. Georg Schett — Erlangen CASTLE study, 2021)
    • Vincenz Czerny Prize — German Society of Hematology and Oncology (DGHO), Vienna, 1994
    • Young Investigator Award — International Association for Endotoxin Research, San Diego, 1990
    • Active President & Founding Director, Bavarian Cancer Research Center (BZKF)
    • Built the Erlangen CAR-T cell production and clinical programme — one of the few European academic CAR-T sites

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