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Dr. Ayman Saad

Acute Leukaemia — Adult Haematology & Stem Cell Transplantation

Dr. Ayman Saad

Consultant, Acute Leukaemia — Adult Haematology & Stem Cell Transplantation

15+ years of experience
MBBS; Internal Medicine Residency; Fellowship in Adult Haematology; Advanced Training in Haematopathology and Flow Cytometry
King Faisal Specialist Hospital, Riyadh - United Arab Emirates

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    Areas of Expertise

    Dr. Ayman Saad

    Major Conditions Treated

    • Acute Myeloid Leukaemia (AML)
    • Acute Lymphoblastic Leukaemia (ALL)
    • Myelodysplastic Syndrome (MDS)
    • Chronic Myeloid Leukaemia (CML)
    • Myeloproliferative Neoplasms
    • Aplastic Anaemia and Bone Marrow Failure (Including ERCC6L2)
    • Graft-versus-Host Disease (Acute and Chronic)
    • Sinusoidal Obstruction Syndrome
    • Relapsed/Refractory B-Cell Lymphoma (CAR-T Candidates)

    Sub-specialties

    • Acute Leukaemia & MDS Management: Evidence-based induction and consolidation chemotherapy, venetoclax-azacitidine regimens, and targeted FLT3/IDH inhibitors — a trusted acute leukaemia specialist in Riyadh for international patients.
    • Stem Cell Transplantation & CAR-T: Autologous, allogeneic, and haploidentical HSCT; CD19-directed CAR-T cell therapy for relapsed/refractory B-cell malignancies.
    • cGVHD & Transplant Complications: Principal investigator on ruxolitinib phase II trial for steroid-refractory sclerotic chronic GVHD; expertise in sinusoidal obstruction syndrome and inotuzumab-related hepatotoxicity management.

    Advanced Procedures & Treatments

    • Induction and Consolidation Chemotherapy for AML/ALL
    • Venetoclax-Azacitidine Regimens for AML and MDS
    • FLT3 / IDH1 / IDH2 Inhibitor Therapy
    • Allogeneic and Haploidentical HSCT
    • CD19 CAR-T Cell Therapy
    • Ruxolitinib for Steroid-Refractory Chronic GVHD
    • Defibrotide for Sinusoidal Obstruction Syndrome
    • Minimal Residual Disease (MRD) Monitoring via Flow Cytometry

    Qualifications & Credentials

    Medical Degrees

    • MBBS — Bachelor of Medicine and Bachelor of Surgery
    • Internal Medicine Residency

    Fellowships & Special Training

    • Fellowship in Adult Haematology
    • Fellowship in Haematopoietic Stem Cell Transplantation
    • Advanced Training in Haematopathology and Flow Cytometry

    Certifications & Accreditations

    • Saudi Commission for Health Specialties (SCFHS) — Registered Consultant
    • American Society of Hematology (ASH) — Member
    • European Society for Blood and Marrow Transplantation (EBMT) — Member

    Professional Experience

    Current Affiliation

    • Consultant Haematologist, Acute Leukaemia Section — King Faisal Specialist Hospital & Research Centre (KFSHRC) Oncology Centre, Riyadh, Saudi Arabia (Present)

    Past Affiliations

    • Fellowship training in Adult Haematology and Stem Cell Transplantation — completed prior to KFSHRC consultancy

    Academic & Research Roles

    • Principal Investigator — multicentre phase II trial of ruxolitinib for sclerotic cGVHD (2022)
    • Contributing Investigator — CD19 CAR-T cell therapy prognostic studies
    • Faculty — KFSHRC Haematology clinical and education programmes

    Key Achievements

    • Lead or co-author on Blood (2024) publications including CAR-T prognostic impact (144:7153), ERCC6L2 bone marrow failure (144:5706), and sinusoidal obstruction syndrome / inotuzumab (144:7306)
    • Principal investigator on phase II trial of ruxolitinib for steroid-refractory sclerotic cGVHD (2022)
    • Expertise spans haematopathology, flow cytometry, and MRD assessment
    • Active in international collaborations on CAR-T outcomes and GVHD

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